Indications

Esomeprazole is indicated:

Treatment of Gastroesophageal Reflux Disease (GERD)

Healing of erosive esophagitis

Maintenance of healing of erosive esophagitis

Symptomatic Gastroesophageal Reflux Disease (GERD)

Reduction of NSAID-associated gastric ulcer

H. pylori eradication (Triple therapy)

Zollinger-Ellison syndrome।

Dosage

Tablet or Capsule:

Healing of erosive esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks. The majority of patients are healed within 4 to 8 weeks. For patients who do not heal after 4-8 weeks, an additional 4-8 weeks treatment may be considered.

Maintenance of healing of erosive esophagitis: 20 mg once daily. Controlled studies did not extend beyond six months.

Symptomatic GERD: 20 mg once daily for 4 weeks. If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered.

H.pylori eradication (Triple therapy): Esomeprazole 20 mg twice daily for 10 days, Amoxicillin 1000 mg Twice daily for 10 days and Clarithromycin 500 mg twice daily for 10 days

Injection: The recommended adult dose in GERD with Erosive Esophagitis is either 20 or 40 mg Esomeprazole given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 to 30 minutes).