Composition

Rice Based Oral Rehydration Salt for 500 ml Water:

Each sachet contains-

Sodium Chloride 1.30 gm

Potassium Chloride 0.75 gm

Tri-Sodium Citrate Dihydrate 1.45 gm

Processed Rice Powder Pharma Grade 25 gm

Rice Based Oral Rehydration Salt for 250 ml Water:

Each sachet contains-

Sodium chloride 0.650 gm

Potassium chloride 0.375 gm

Tri-Sodium Citrate Dihydrate 0.725 gm

Processed Rice Powder Pharma Grade 12.50 gm.

Indications

Acute fluid and electrolyte loss conditions such as cholera, acute diarrhoea & vomiting, Dehydration, Severely low concentrations of salts in the blood (severe electrolyte depletion)

Therapeutic Class

Oral electrolytes preparations

Pharmacology

This contains essential electrolytes & carbohydrate (in the form of processed rice) which are vital for a dehydrating patient in conditions such as cholera, acute diarrhoea, vomiting & excessive sweating.

In the normal healthy intestine, there is a continuous exchange of water through the intestinal wall – up to 20 liters of water is secreted and very nearly as much is reabsorbed every 24 hours – this mechanism allows the absorption of soluble metabolites from digested food into the bloodstream.

In a state of diarrheal disease the balance is upset and much more water is secreted than is reabsorbed causing a net loss to the body which can be as high as several liters a day. In addition to water, Chloride ion (CI-), extracellular sodium ion (Na+) & intracellular potassium ion (K+) are also lost. This is effectively replenishes the lost electrolytes in the body.

Dosage

Dose depends on the severity of the dehydrating conditions of the patients. Age Recommended Dose after each watery stool:

6 months to 2 years: 50 ml to 100 ml (10 to 20 Teaspoonfuls)

2 years to 9 years: 100 ml to 200 ml (20 to 40 teaspoonfuls)

10 years and above: 250 ml to 500 ml (1 to 2 glassfuls)

Administration

Discard any unused reconstituted saline after 5 hours of preparation After preparing the saline further heating or boiling is not necessary Feeding-bottle should not be used

Mix the solution with a clean spoon each time before administration

Syringe without needle may be used to put small amount of saline into babies mouth

Contraindications

Kidney failure resulting in diminished production of urine (oliguria) Kidney failure, preventing production of urine (anuria)

Obstruction of the stomach or intestines Reduced blood flow to vital internal organs (shock)

Severe and continuous vomiting (intractable vomiting)

Severe dehydration Severe diarrhoea in infants

Pregnancy & Lactation

Recommended in pregnancy & lactation, as there is no known harmful effects when this medicine is used.

Precautions & Warnings

Precautions should be taken in case of significant overdose, especially for the following patients -Children less than 1 year of age. Patients with imbalance of salt concentrations in the blood (electrolyte imbalance) Patients with severely decreased kidney function Patients with severely decreased liver function

Reconstitution

Preparation for 250 ml Saline: Wash both hands with soap before preparing the saline. Add 250 ml (one glassful) hot boiled water into a jar.Then add full sachet of Rice ORS® (for 250 ml water) powder into the jar. Mix the powder well in the water until a milky white solution appears. Give the solution to the patient to drink as per the dose.

Preparation for 500 ml Saline: Wash both hands with soap before preparing the saline. Add 500 ml hot boiled water (two glassfuls) into a jar. Then add full sachet of Rice ORS* (for 500 ml water) powder into the jar. Mix the powder well in the water until a milky white solution appears. Give the solution to the patient to drink as per the dose.

Storage Conditions

Store in a cool & dry place, protected from light & moisture.