Introduction

Progut 40 Capsule is a medicine which reduces the amount of acid produced in your stomach. It is used to treat heartburn, acid reflux and problems in yo... View More

Uses of Progut 40 Capsule

• Gastroesophageal reflux disease (Acid reflux)
• Peptic ulcer disease

Side effects of Progut 40 Capsule

• Headache
• Dizziness
• Dryness in mouth
• Nausea
• Abdominal pain
• Constipation
• Flatulence
• Diarrhea

How to use Progut 40 Capsule

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Progut 40 Capsule is to be... View More

How Progut 40 Capsule works

Progut 40 Capsule is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indiges... View More

What if you forget to take Progut 40 Capsule?

If you miss a dose of Progut 40 Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back... View More

Indication

Heartburn, Acid Related Dyspepsia, Peptic ulcer disease, Zollinger-Ellison syndrome, Gastroesophageal reflux disease (GERD), Helicobacter pylori infecti... View More

Administration

Delayed-release cap: Should be taken on an empty stomach. Take on an empty stomach 1 hr before meals. Tab: May be taken with or without food.

Adult Dose

GERD Without Erosive Esophagitis 20 mg PO qDay for 4 weeks; consider an additional 4 weeks of treatment if symptoms do not resolve completely in the fi... View More

Child Dose

GERD Without Erosive Esophagitis Oral <1 year: Safety and efficacy not established 1-12 years: 10-20 mg PO qDay for up to 8 weeks >12 years: 20-40 m... View More

Renal Dose

Renal impairment: No dosage adjustment needed.

Contraindication

Esomeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted Benzimidazoles.

Mode of Action

Esomeprazole is a PPI that suppresses gastric acid secretion by inhibiting H+/K+ ATPase in the gastric parietal cell. It is the S-isomer of omeprazole.

Precaution

Paediatric; pregnancy, lactation. Malignancy and hepatic impairment. Increased risk of developing certain infections such as community-acquired pneumoni... View More

Side Effect

>10% Headache (2-11%) 1-10% Flatulence (10%),Indigestion (6%),Nausea (6%),Abdominal pain (1-6%),Diarrhea (2-4%),Xerostomia (3-4%),Dizziness (2-3%),... View More

Pregnancy Category Note

Pregnancy There are no adequate and well-controlled studies in pregnant women; esomeprazole is the S-isomer of omeprazole; available epidemiologic data... View More

Interaction

Increased risk of digoxin-induced cardiotoxic effects. Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time w/ warfarin... View More