Indication

Heartburn, Acid Related Dyspepsia, Peptic ulcer disease, Zollinger-Ellison syndrome, Gastroesophageal reflux disease (GERD), Helicobacter pylori infecti... View More

Administration

Reconstitution: Each single-use vial contains 20 or 40 mg of esomeprazole. For IV inj: Reconstitute each vial w/ 5 mL of normal saline and consume w... View More

Adult Dose

Intravenous Gastro-oesophageal reflux disease Adult: 20 or 40 mg by inj over at least 3 min or infusion over 10-30 min once daily for <10 days. Conver... View More

Child Dose

Short-term Treatment of GERD IV Short-term treatment of GERD with erosive esophagitis when oral therapy is not possible or appropriate <1 month: Safe... View More

Renal Dose

Renal impairment: No dosage adjustment needed.

Contraindication

Esomeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted Benzimidazoles.

Mode of Action

Esomeprazole is a PPI that suppresses gastric acid secretion by inhibiting H+/K+ ATPase in the gastric parietal cell. It is the S-isomer of omeprazole.

Precaution

Paediatric; pregnancy, lactation. Malignancy and hepatic impairment. Increased risk of developing certain infections such as community-acquired pneumoni... View More

Side Effect

>10% Headache (2-11%) 1-10% Flatulence (10%),Indigestion (6%),Nausea (6%),Abdominal pain (1-6%),Diarrhea (2-4%),Xerostomia (3-4%),Dizziness (2-3%),... View More

Pregnancy Category Note

Pregnancy There are no adequate and well-controlled studies in pregnant women; esomeprazole is the S-isomer of omeprazole; available epidemiologic data... View More

Interaction

Increased risk of digoxin-induced cardiotoxic effects. Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time w/ warfarin... View