Generic

Protamine Crystallised Insulin Aspart

Indications

Protamine Crystallised Insulin Aspart is an insulin analog used to help diabetic patients achieve better glycemic control.

Pharmacology

Insulin Aspart's major function is to regulate glucose metabolism. Insulin Aspart binds to insulin receptors in muscle and fat cells, lowering blood glucose levels by facilitating cellular glucose uptake while also inhibiting glucose production from the liver.

Dosage & Administration

Insulin Aspart has a faster onset and a shorter duration of action than soluble human insulin. Due to the faster onset of action, Insulin Aspart should generally be given immediately before a meal. When necessary Insulin Aspart may be given soon after a meal.

Dosage of Insulin Aspart is individual and determined on the basis of the physician's advice in accordance with the needs of the patient. It should normally be used in combination with long-acting insulin given at least once a day.

The individual insulin requirement is usually between 0.5 and 1.0 IU/kg/day in adults and children over 2 years of age. In a meal-related treatment 50-70% of this requirement may be provided by Insulin Aspart and the remainder by long-acting insulin. Adjustment of dosage may also be necessary if patients undertake increased physical activity or change their usual diet. Exercise taken immediately after a meal may increase the risk of hypoglycaemia.

Subcutaneous Injection: Insulin Aspart should be administered by subcutaneous injection in the abdominal region, buttocks, thigh, or upper arm. Because Insulin Aspart has a more rapid onset and a shorter duration of activity than human regular insulin, it should be injected immediately (within 5-10 minutes) before a meal Continuous Subcutaneous Insulin Infusion (CSII) by External Pump Insulin Aspart can also be infused subcutaneously by an external insulin pump. The initial programming of the external insulin infusion pump should be based on the total daily insulin dose of the previous regimen. Approximately 50% of the total dose is usually given as meal-related boluses of Insulin Aspart and the remainder is given as a basal infusion. When used with an infusion pump Insulin Aspart should not be mixed with any other insulin.

Intravenous Use: Insulin Aspart can be administered intravenously under medical supervision for glycemic control with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia. For intravenous use, Insulin Aspart should be used at concentrations from 0.05 IU/mL to 1.0 IU/mL insulin aspart in infusion systems using polypropylene infusion bags. Insulin Aspart has been shown to be stable in infusion fluids such as 0.9% sodium chloride.

Interaction

A variety of medications have an effect on glucose metabolism and may necessitate dosage adjustments.

Insulin and Insulin Aspart needs may be reduced by the following substances: Angiotensin-converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, propoxyphene, pentoxifylline, salicylates, and sulfonamide antibiotics are all examples of oral anti-diabetic medications.

Thiazides, glucocorticoids, thyroid hormones, beta-sympathomimetics, growth hormone, and danazol are all drugs that can raise Insulin and Insulin Aspart needs. Beta-blockers, clonidine, lithium salts, and alcohol can either increase or decrease insulin's blood glucose lowering action.

Side Effects

Hypoglycemia, allergic responses, injection site reaction, lipodystrophy, pruritus, and rash are among side effects of Insulin Aspart.

Pregnancy & Lactation

Category B pregnancy. Treatment with Protamine Crystallised Insulin Aspart is not restricted during lactation. The baby should not be harmed by the mother's insulin medication. However, it's possible that the dosage will need to be changed.

Precautions & Warnings

Dose adjustment and monitoring: All insulin-treated individuals should have their blood glucose levels checked on a regular basis. Insulin regimes should only be changed with caution and under medical supervision.

Therapeutic Class

Insulin that works quickly.

Storage Conditions

Refrigerate between 2 and 8 degrees Celsius. Do not allow yourself to become frozen. Protect yourself from the sun.

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.