Generic

Etodolac

Indications

Etodolac is prescribed for the treatment of the following signs and symptoms, both acutely and long-term:

Pharmacology

The anti-inflammatory effects of etodolac, like those of other NSAIDs, are due to suppression of the enzyme cycooxygenase (COX). This reduces the production of peripheral prostaglandins, which are important mediators of inflammation. Etodolac binds to the upper region of the COX enzyme active site, preventing arachidonic acid, the enzyme's substrate, from entering. Etodolac was once assumed to be a non-selective COX inhibitor, however it has since been discovered to be 5-50 times more selective for COX-2 than COX-1. Antipyresis can be caused by central hypothalamic activation, which causes peripheral dilatation, increased cutaneous blood flow, and heat loss.

Dosage & Administration

Adults and over 18 years:

Etodolac 300 mg capsule: 600 mg daily in 1-2 divided doses

Etodolac 600 mg ER tablet: Once daily

Pediatric: Safety and effectiveness in pediatric patients below the age of 18 years have not been established.

Interaction

According to certain reports, NSAIDs may reduce the antihypertensive impact of ACE inhibitors. In patients taking NSAIDs and ACE inhibitors at the same time, this interaction should be taken into account. When Etodolac is combined with Aspirin, its protein binding is reduced, but free Etodolac clearance is unaffected. The therapeutic significance of this interaction is unknown; nonetheless, like with other NSAIDs, taking Etodolac and Aspirin at the same time is not suggested due to the risk of increased side effects.

Contraindications

Patients who have a known hypersensitivity to Etodolac should avoid taking it. Patients who have had asthma, urticaria, or other allergic responses after taking aspirin or other NSAIDs should not take Etodolac.

Side Effects

The gastrointestinal system is one of Etodolac's most common adverse effects. Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, heartburn, nausea, Gl ulcers, and vomiting are all possible side effects. Anemia, dizziness, edema, raised liver enzymes, headaches, increased bleeding time, pruritis, rashes, tinnitus, and other symptoms may occur.

Pregnancy & Lactation

In pregnant women, there are no sufficient and well-controlled trials. Only if the possible benefit outweighs the risk to the fetus should it be taken during pregnancy. Etodolac is not known to be excreted in human milk. Considering the medicine's value to the mother, a decision should be taken whether to quit nursing or discontinue the drug.

Precautions & Warnings

In individuals with severe hepatic responses, pre-existing asthma, fluid retention, hypertension, or heart failure, etodolac should be used with caution. It should be stopped if clinical signs and symptoms of liver disease appear, or if systemic features (eosinophilia, dermatitis, etc.) appear.

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.