Inhouse product
Duloxetine Hydrochloride
Duloxetine Hydrochloride is an orally administered selective serotonin and norepinephrine reuptake inhibitor (SSNRI). Duloxetine is a less powerful dopamine reuptake inhibitor. In vitro, dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors have no appreciable affinity for duloxetine. Monoamine oxidase is not inhibited by duloxetine (MAO). Duloxetine hydrochloride is well absorbed when taken orally. Duloxetine is primarily eliminated by hepatic metabolism.
Duloxetine metabolism is controlled by the CYP1A2 and CYP2D6 isozymes. The AUC, Cmax, and t of Duloxetine were all enhanced when it was given with fluvoxamine, a powerful CYP1A2 inhibitor. Cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin are examples of medicines that impede CYP1A2 metabolism, therefore these combinations should be avoided. Because CYP2D6 is involved in Duloxetine metabolism, combining Duloxetine with CYP2D6 inhibitors may result in increased Duloxetine concentrations.
Patients who have a known hypersensitivity to duloxetine or any of its inactive components should avoid it. Duloxetine is not approved for the treatment of bipolar disorder. Patients with a history of heavy drinking or symptoms of chronic liver damage should not be prescribed duloxetine. Duloxetine has been linked to an increased risk of mydriasis in clinical trials, thus it should be used with caution in individuals with managed narrow-angle glaucoma.
Nausea, dizziness, dry mouth, constipation, decreased appetite, fatigue, somnolence, increased perspiration, hyperhidrosis, and asthenia were the most commonly reported side effects in Duloxetine hydrochloride patients. It may cause a small rise in blood pressure. Between Duloxetine-treated and placebo-treated patients, there were no clinically significant variations in QT, PR, and QRS intervals.
Pregnancy is classified as Category C. Due to the lack of rigorous and well-controlled trials in pregnant women, Duloxetine should only be used during pregnancy if the potential benefit outweighs the risk to the fetus.Human Labor and Delivery: The effects of Duloxetine on human labor and delivery are unknown. Only if the possible benefit outweighs the risk to the fetus may duloxetine be administered during labor and delivery.Duloxetine and/or its metabolites are not known to be excreted in human milk, hence nursing while taking Duloxetine is not suggested.
All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes. Blood pressure should be measured prior to initiating treatment and periodically measured throughout treatment. Patients should be cautioned about the risk of bleeding associated with the concomitant use of Duloxetine and NSAIDs, aspirin, or other drugs that affect coagulation. Duloxetine should be used cautiously in patients with a history of mania. Duloxetine should be prescribed with care in patients with a history of a seizure disorder.
Inhibitor of serotonin-norepinephrine reuptake (SNRI)
Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.
Incepta Pharmaceuticals Ltd.
Duloxen 20
MShopBD-Majumder Shop Online Shopping in Bangladesh is the Best Shopping store within 10000+ products cash on delivery in dhaka, Khulna, ctg & all over Bangladesh with COD-cash on delivery (Only Shipping Cost Advance ) under by www.esdp.gov.bd (bangladesh.gov.bd ) Home Delivery all Over Bangladesh different location and shop as like as Multivendor Online Sites in BD.