Miconazole has antifungal and antibacterial properties against common dermatophytes and yeasts. It also has antifungal and antibacterial properties against specific gram-positive bacilli and cocci. Its action is dependent on the suppression of an ergosterol biosynthesis demethylation step. Ergosterol is the major sterol in yeast and fungus and is produced as a byproduct of the metabolic process. The ergosterol production is disrupted, causing holes to form in the fungal cell membrane. These pores allow the fungal cells' critical elements to flow out, causing the cells to perish.
Miconazole has a limited oral bioavailability (25-30%) due to intestinal absorption. Miconazole is absorbed systemically after being given as an oral gel. Miconazole is linked to plasma proteins (88.2%), predominantly serum albumin and red blood cells, after absorption (10.6 percent ). Miconazole oral gel is processed to a great extent; less than 1% of the administered dose is excreted unaltered in the urine. In most people, the terminal plasma half-life is 20-25 hours. Miconazole has a comparable elimination half-life in all renally compromised patients.
Oropharyngeal candidosis-
Gastrointestinal tract candidosis-
Missed Dose: Apply the missed dose as soon as you remember. In case of next dosing time, omit the missed
dose and continue your usual course.
Miconazole should not be used in patients who have a history of hypersensitivity to the active component.
Long-term use may cause nausea and vomiting, as well as diarrhea and allergic responses.
There is no information about Miconazole oral gel's safety during pregnancy. Miconazole oral gel should be avoided during pregnancy if at all possible, or the risks should be weighed against the benefits. Miconazole should be provided with caution to a nursing mother because many medications are excreted in human milk.
If Miconazole and an anticoagulant are used together, the anticoagulant impact should be monitored and titrated. When taking miconazole and phenytoin at the same time, blood levels should be checked. In newborns and young children, care must be taken to avoid obstructing the throat with the gel.
Aural Anti-fungal preparations
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