Introduction

Uromax 0.4 is an alpha adrenergic antagonist that is used in the treatment of benign prostatic hyperplasia. It helps to relieve symptoms like difficulty in passing urine. However, it does not decrease the size of the prostate. Uromax 0.4 is advised to take it in a dose and duration as per prescription. It should be taken with food, but take at the same time regularly. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy of the medicine. Some common side effects of this medicine are headache and tiredness. It may also lead to blurry vision or dizziness, so it is advised to avoid driving while on the medication. If any of the side effects persist or bother you, you must consult the doctor without delay. Simple lifestyle changes can help you manage your symptoms better. Try to urinate as soon as you feel the urge, however, never strain or push to empty your bladder. You should avoid drinking caffeinated or alcoholic drinks at night and a few hours before going to bed or going out. Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. If you are pregnant or breastfeeding, tell your doctor prior to the treatment. If you have to undergo eye surgery due to cataract or glaucoma than inform your eye doctor about the usage of this medicine. Patients with liver or kidney disease must be cautious while receiving the prescription, and they must receive regular follow-ups as per the doctor's advice.

Uses of Uromax 0.4

• Benign prostatic hyperplasia

Side effects of Uromax 0.4

• Retrograde ejaculation
• Dizziness
• Nasal congestion (stuffy nose)

How to use Uromax 0.4

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Uromax 0.4 is to be taken with food.

How Uromax 0.4 works

Uromax 0.4 is an alpha blocker. It works by relaxing the muscles around the bladder exit and prostate gland so urine is passed more easily. This helps empty the bladder completely and reduces the need to pass urine frequently or urgently in BPH.

What if you forget to take Uromax 0.4?

If you miss a dose of Uromax 0.4, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Indication

Benign prostatic hyperplasia

Administration

Prolonged release tab: May be taken with or without food. Swallow whole, do not chew/crush. Cap: Should be taken with food. Take ½ hr following the same meal daily. Swallow whole, do not open/chew/crush.

Adult Dose

Oral Benign prostatic hyperplasia Adult: 1 (400mcg) capsule once daily. If response is inadequate after 2-4 weeks, may be increased to 800 mcg once daily; if therapy is interrupted, should be resumed at 400 mcg once daily Hepatic impairment Mild to moderate: Dosage adjustment not necessary Severe: Not studied

Renal Dose

Renal impairment CrCl ?10 mL/min: Dosage adjustment not necessary CrCl <10 mL/min: Not studied

Contraindication

Hypersensitivity to sulfonamide, severe hepatic impairment, lactation. History of orthostatic hypotension.

Mode of Action

Tamsulosin is a selective alpha1 adrenoreceptor-blocking agent. Smooth muscle tone is mediated by the sympathetic nervous stimulation of alpha1 adrenoreceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck. Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and reduction in symptoms in BPH.

Precaution

Hypersensitivity to Tamsulosin Hydrochloride. A history of orthostatic hypotension; severe hepatic insufficiency. As with other alpha1 blockers, a reduction in blood pressure can occur in individual cases during treatment with Tamsulosin, as a result of which, rarely, syncope can occur. At the first signs of orthostatic hypotension (dizziness, weakness) the patient should sit or lie down until the symptoms have disappeared. And they should be cautioned to avoid situations where injury could result (like driving, operating machinery or performing hazardous tasks). Before therapy with Tamsulosin is initiated the patient should be examined in order to exclude the presence of other conditions which can cause the same symptoms as Benign Prostatic Hyperplasia. Digital rectal examination and when necessary determination of Prostate Specific Antigen (PSA) should be performed before treatment and at regular intervals afterwards. The treatment of severely renal impaired patients (creatinine clearance is less than10ml/min) should be approached with caution as these patients have not been studied. Caution should be exercised in porphyria or allergic reaction to this or any other medicine.

Side Effect

>10% Headache (19-21%),Orthostatic hypotension (6-19%),Rhinitis (13-18%),Abnormal ejaculation (8-18%),Dizziness (15-17%),Arthralgia (11%),Infection (9-11%) 1-10% Asthenia (8%),Back pain (7-8%),Skin rash (7%),Pharyngitis (5-6%),Diarrhea (4-6%),Myalgia (5%),Chest pain (4%),Cough (3-4%),Somnolence (3-4%),Nausea (2-4%),Sinusitis (2-4%),Abdominal discomfort (2-3%),Bitter taste (2-3%),Decreased libido (1-2%),Insomnia (1-2%)

Interaction

Increased plasma concentration w/ strong CYP3A4 inhibitors (e.g. ketoconazole). Moderate CYP3A4 inhibitors (e.g. erythromycin), strong (e.g. paroxetine) or moderate (e.g. terbinafine) CYP2D6 inhibitors may increase exposure of tamsulosin. Increased plasma concentration w/ cimetidine. Additive effect w/ other ?-adrenergic blocking agents. Concomitant use w/ PDE5 inhibitors may lead to symptomatic hypotension. Decreased plasma concentration w/ furosemide.