Generic

Indapamide

Indications

Indapamide is prescribed to treat essential hypertension. It is helpful in treating hypertension in people with impaired renal function, however its diuretic impact is diminished. Indapamide is also used to treat salt and fluid retention caused by congestive heart failure.

Pharmacology

Indapamide is an antihypertensive diuretic. It appears to produce vasodilation by blocking the flow of calcium and other ions (such as sodium and potassium) through membranes. It has an extrarenal antihypertensive effect that reduces vascular hyperreactivity as well as total peripheral and arteriolar resistance.

Dosage & Administration

One tablet daily preferably in the morning. In more sever case Indapamide can be combine with other categories of anti-hypertensive agent. The safety and effectiveness in pediatric patients have not been established

Interaction

Other antihypertensive: Indapamide may supplement or enhance the effect of other antihypertensive medications.

Indapamide, like thiazides, may reduce arterial reactivity to norepinephrine.

Diuretics should not be administered concurrently with lithium because they decrease renal clearance and increase the risk of lithium toxicity.

Contraindications

This drug must not be taken in the following conditions:

• Sulfonamide hypersensitivity
• Renal failure that is severe
• Hepatic encephalopathy, often known as severe hepatic failure
• Hypokalaemia

Side Effects

Indapamide side effects include headache, anorexia, stomach irritation, nausea, vomiting, constipation, diarrhoea, and others.

Pregnancy & Lactation

Indapamide is not advised since there are no sufficient and well-controlled trials in pregnant women. Breastfeeding should be avoided by mothers who are taking Indapamide.

Precautions & Warnings

Serum potassium and uric acid levels should be monitored, especially in people with a tendency or susceptibility to hypokalemia and in gout patients. Despite the fact that no adverse symptoms were recorded during clinical trials, patients with a history of sulfonamide derivative sensitivity should be cautiously watched.

Therapeutic Class

Thiazide diuretics and related medications

Storage Conditions

Keep in a cool, dry place. Keep out of direct sunlight and dampness.

Pharmaceutical Name

Servier Bangladesh Operation