Generic

Dopamine Hydrochloride

Indications

Dopamine is used to treat haemodynamic imbalances such as acute hypotension or shock caused by myocardial infarction, endotoxic septicaemia, trauma, or renal failure.

When there is prolonged hypotension after treatment of hypovolaemia after open heart surgery.

As in congestive failure, persistent cardiac decompensation.

Pharmacology

Acute hypotension or shock linked with myocardial infarction, endotoxic septicaemia, trauma, or renal failure should be treated with dopamine.

When there is prolonged hypotension after treatment of hypovolaemia after open heart surgery, this drug can be used as an adjuvant.

As in congestive failure, in persistent cardiac decompensation.

Dosage & Administration

Intravenous-

Acute heart failure:

Adult: Initially, 2-5 mcg/kg/min, increased gradually by up to 5-10 mcg/kg/min according to patient’s cardiac and urine output. Seriously ill patient: Up to 20-50 mcg/kg/min may be required.

Interaction

The arrhythmogenic impact of dopamine may be enhanced by cyclopropane and halogenated hydrocarbon anesthetics. -adrenergic agents counteract cardiac effects (e.g. propanolol, metoprolol). The vasoconstricting effect of high dose dopamine may be counteracted by -adrenergic blocking drugs. MAOIs have a longer-lasting and stronger effect. With phenytoin, there is a risk of hypotension and bradycardia. Hydrochlorothiazide or furosemide's diuretic impact may be amplified. TCAs and guanethidine have a stronger vasopressor impact. Ergot alkaloids may cause significant vasoconstriction.

Contraindications

Pheochromocytoma, atrial or ventricular tachyarrhythmias, ventricular fibrillation, hyperthyroidism, and concurrent usage with ergotamine are all contraindications to dopamine administration.

Side Effects

Angina, tachycardia, palpitation, hypotension, vasoconstriction, dyspnoea, nausea, vomiting, headache, cardiac conduction abnormalities, HTN, azotemia, anxiety, widened QRS complex, bradycardia, piloerection, peripheral cyanosis, cardiac conduction abnormalities, HTN, azotemia, anxiety, widened QRS complex, bradycardia, piloer

Pregnancy & Lactation

It is unknown whether dopamine passes the placental barrier during pregnancy. The advantages of using this product must be balanced against the potential hazards to the fetus.

Lactation: It is not advised for moms who are breast-feeding unless the expected advantages outweigh the potential dangers.

Precautions & Warnings

Active myocardial ischaemia or recent MI in a patient with CV disease, cardiac arrhythmias, and/or occlusive vascular disease. Prior to treatment, correct hypovolemia. Lactation and pregnancy.

Therapeutic Class

Inotropic-sympathomimetics.

Storage Conditions

Protect from light and store below 30°C.

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.