Generic

Moxifloxacin Hydrochloride

Indications

Moxifloxacin is used to treat acute bacterial sinusitis, acute aggravation of chronic bronchitis, community-acquired pneumonia, simple and difficult skin and skin structure infections, complex intra-abdominal infections, and pelvic inflammatory disease.

Pharmacology

Moxifloxacin is a fluoroquinolone class antibacterial medication of the fourth generation. It is active against a wide spectrum of microorganisms, including Mycoplasma pneumoniae, that are gram-positive, gram-negative, anaerobic, or atypical. It works by blocking topoisomerases II (DNA gyrase) and IV, which are required for bacterial DNA replication, transcription, and repair.

Dosage & Administration

Acute bacterial sinusitis: 400 mg once daily 7-10 days.

Acute bacterial exacerbation of chronic bronchitis: 400 mg once daily 5-10 days.

Community-acquired pneumonia: 400 mg once daily 7-14 days.

Uncomplicated skin and skin structure infections: 400 mg once daily 7 days.

Complicated skin and skin structure infections: 400 mg once daily 7-21 days.

Complicated intra-abdominal infections: 400 mg once daily 5-14 days.

Pelvic inflammatory disease: 400 mg once daily 14 days.

Interaction

When antacids, sucralfate, multivitamins, and multivalent cations are combined with loxifloxacin, absorption is reduced (e.g. iron or zinc). Moxifloxacin may increase the risk of seizures when used with NSAIDs and bleeding when combined with warfarin. As a result, using Moxifloxacin with them should be avoided.

Contraindications

It is not recommended for individuals who have previously had hypersensitivity to Moxifloxacin or other quinolones.

Side Effects

Nausea, vomiting, diarrhea, headache, and dizziness are common adverse effects of Moxifloxacin.

Pregnancy & Lactation

Pregnancy category C according to the US Food and Drug Administration. Moxifloxacin is not advised to be used during pregnancy or breastfeeding.

Precautions & Warnings

Moxifloxacin may increase the likelihood of tendinitis and tendon rupture. It should be stopped if there is discomfort or inflammation in a tendon. It should not be used in patients who have a known QT interval prolongation, patients who have uncorrected hypokalemia, or patients who are receiving Class IA or Class III antiarrhythmic medicines.

Therapeutic Class

4-Quinolone preparations

Storage Conditions

Store in a cool, dry area away from light and heat. Keep out of children's reach.

Pharmaceutical Name

Incepta Pharmaceuticals Ltd