Inhouse product
Indications
This is indicated to relieve symptoms of dyspepsia, heartburn, acid indigestion, sour stomach, gastroesophageal reflux and hiatal hernia. It is also prescribed in hyperacidity associated with peptic ulcers, gastritis and esophagitis. Magaldrate may be given to children if necessary. Also indicated for the relief of flatulence, abdominal distension and windy colic.
Therapeutic Class
Antacids, Anti-dyspeptic/Carminatives
Pharmacology
Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly in gastric acid to Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect Simethicone lowers surface tension and facilitates gas dispersion by causing coalescence of gas bubbles in the GI tract, thus helping in their dispersion.
Dosage & Administration
Tablet (Adult): 1-3 tablet, after meals and at bed time or as directed by the physician. Suspension (Adult): 2-4 teaspoonfuls after 20-60 minutes of meal and before sleep or on the basis of physician’s prescription. Use in children: Not recommended in children under 6 years of age unless, directed by physician.
Interaction
It should not be used in patients taking any form of Tetracycline. The drug may cause reduced bio-availability or slower absorption of a number of drugs including propranolol, isoniazid, prednisolone and naproxen.
Contraindications
Magaldrate is contraindicated in patients with known hypersensitivity to magnesium and aluminium. It is also contraindicated in patients with impaired renal functions.
Side Effects
GI side-effects are uncommon. Occasionally, if excessive amount is consumed, diarrhea, constipation or regurgitation may occur.
Pregnancy & Lactation
Pregnant women: Magaldrate may be used in pregnancy if indicated. However one should avoid excessive dosage. Lactating mother: Magaldrate may pass into breast milk but has not been reported to cause problem in nursing babies.
Precautions & Warnings
Care should be taken in decreased kidney function, hypophosphataemia and weak people.
Overdose Effects
Over dosage with this formulation is a rare case.
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