Emestop Capsule 40 mg (4Pcs)

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Indications of Emestop

Emestop is suitable for:

  • prevention of postoperative nausea and vomiting (PONV)
  • prevention of nausea and vomiting caused by chemotherapy (NVCV)

 

Pharmaceutical Name of Emestop

Incepta Pharmaceuticals Ltd

 

Pharmacology of Emestop

Aprepitant is a selective high-affinity antagonist of the human substance P neurokinin 1 (NK1) receptor. When substance P binds to these receptors, it can cause nausea and vomiting. Aprepitant prevents substance P from binding to NK1 receptors. By blocking the receptor, aprepitant can prevent nausea and vomiting, which usually occurs after chemotherapy or as a complication of surgery.

 

Dosage & Administration

Post Operative Nausea and Vomiting: The recommended oral dosage of Aprepitant is 40 mg within 3 hours prior to induction of anesthesia.

Chemotherapy-Induced Nausea and Vomiting:

** The following regimen should be used for the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy-

  • Day 1: Aprepitant 125 mg orally, Dexamethasone 12 mg orally, 5-HT3 antagonist (Ondansetron): 24 mg 30 minutes before the start of chemotherapy.
  • Day 2: Aprepitant 80 mg orally, Dexamethasone 8 mg orally
  • Day 3: Aprepitant 80 mg orally, Dexamethasone 8 mg orally
  • Day 4: Dexamethasone 8 mg orally

Aprepitant is administered orally 1 hour prior to chemotherapy treatment on Day 1 and in the morning on Days 2 and 3. Dexamethasone is administered 30 minutes prior to chemotherapy treatment on Day 1 and in the morning on Days 2 through 4. The dose of dexamethasone accounts for drug interactions.

** The following regimen should be used for the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy:

  • Day 1: Aprepitant 125 mg orally, Dexamethasone 12 mg orally, 5-HT3 antagonist (Ondansetron): one 8 mg tablet 30 minutes before chemotherapy followed by an 8 mg dose 8 hours later.
  • Day 2: Aprepitant 80 mg orally, 5-HT3 antagonist (Ondansetron): 8 mg tablet twice a day
  • Day 3: Aprepitant 80 mg orally, 5-HT3 antagonist (Ondansetron): 8 mg tablet twice a day.

Aprepitant is administered orally 1 hour prior to chemotherapy treatment on Day 1 and in the morning on Days 2 and 3. Dexamethasone is administered 30 minutes prior to chemotherapy treatment on Day 1. The dose of dexamethasone accounts for drug interactions.

 

Interaction of Emestop

Aprepitant is a substrate, moderately weak inhibitor (dose dependent) and CYP3A4 inducer. Aprepitant is also an inducer of CYP2C9. Combine aprepitant with drugs that use CYP3A4 or CYP2C9 (such as warfarin, tolbutamide, phenytoin, ketoconazole, itraconazole, nefazodone, aspergillin, clarithromycin, ritona Wei, nelfinavir, dilatomycin, ritonavir, dilatomycin, ritonavir, etc. During and 28 days after the last dose of aprepitant, the effectiveness of hormonal contraceptives may be Will decrease. During treatment with aprepitant and within 1 month after the last dose of aprepitant, alternative or backup contraceptive methods should be used.

 

Contraindications

Patients who are allergic to any component of this product should not use aprepitant. Aprepitant should not be used with pimozide, terfenadine, astemizole and cisapride at the same time.

 

Side Effects of Emestop

Constipation, hypotension, itching, fever

 

Pregnancy & Lactation

Pregnancy category B. This medicine should be used during pregnancy only if it is clearly needed. It is not known whether this drug will be excreted in human milk. The decision to stop breastfeeding or drug withdrawal should be based on the importance of the patient.

 

Precautions & Warnings

The relief provided by metoclopramide may delay the recognition of serious illnesses. Therefore, metoclopramide should not be prescribed until the diagnosis is made. should warn patients not to engage in potentially dangerous activities that require vigilance, such as driving a car or operating machinery, within a few hours after administration. The same precautions apply to children’s activities, such as cycling or playing near traffic.

 

Therapeutic Class

Anti-emetic drugs

 

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

 

Generic Name of Emestop

Aprepitant

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