Emenil Plus Tablet 25 mg+50 mg (10Pcs)

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Generic

Meclizine + Pyridoxine

 

Indications

Nausea, vomiting, dizziness, motion sickness, radiation sickness, and vertigo are symptoms of illnesses of the vestibular system (e.g., Meniere's syndrome, labyrinthitis, and other vestibular abnormalities) that can be prevented and treated.

 

Pharmacology

Meclizine is an antihistamine that is derived from piperazine. It is also used as an antiemetic. Antiemetic, anticholinergic, and antihistaminic activities are all present. It makes the labyrinthine apparatus less sensitive. The action could be mediated by neuronal paths from the chemoreceptor trigger zone (CTZ) to the vomiting center (VC), peripheral nerve pathways to the VC, or other CNS centers. Vitamin B-6 is pyridoxine. It was added to boost the anti-emetic properties and as a food supplement.

 

Dosage & Administration

Adult and Children 12 years of age & over:

Nausea and vomiting: 25-50 mg daily or as directed by a physician.

Motion sickness: Take an initial dose of 25-50 mg, 1 hour prior to travel. May repeat the dose every 24 hours for the duration of the journey.

Radiation sickness: 50 mg administered 2-12 hours prior to radiation treatment.

Vertigo: 25-100 mg daily in divided doses.

Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP): 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours.

The safety and efficacy for use in children less than 12 years of age have not been established.

 

Interaction

Concurrent use of Ethanol or other CNS depressants such as Benzodiazepines, Barbiturates, Tricyclic antidepressants, opiate agonists, skeletal muscle relaxants, and antihistamines can potentiate Meclizine's CNS depressive effects. The anticholinergic effects of Meclizine can be amplified if you take it with other anticholinergics. Meclizine reduces gastrointestinal motility, which can improve digoxin absorption.

 

Contraindications

Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.

 

Side Effects

Drowsiness, dry mouth and, on rare occasions, blurred vision have been reported.

 

Pregnancy & Lactation

Pregnancy Classification B. Human investigations on a large scale have found no negative effects on the fetus. Meclizine has been indicated as the medicine of choice for treating nausea and vomiting during pregnancy, based on available data, because it has the lowest risk of teratogenicity. It has not been determined whether or not it is safe to use in a breastfeeding mother.

 

Precautions & Warnings

Pregnancy Classification B. Human investigations on a large scale have found no negative effects on the fetus. Meclizine has been indicated as the medicine of choice for treating nausea and vomiting during pregnancy, based on available data, because it has the lowest risk of teratogenicity. It has not been determined whether or not it is safe to use in a breastfeeding mother.

 

Therapeutic Class

Anti-emetic drugs

 

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

 

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.

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