Indications

Hypercalcemia (e.g. in hyperparathyroidism, vitamin-D overdosage, decalcifying tumors such as plasmocytoma, bone metastases); severe hypercalciuria; severe renal failure.

Patients with hyperoxalauria, glucose-6- phosphate dehydrogenase deficiency, or iron overload. Larger doses may lead to gastrointestinal tract upset.

Pharmacology

In humans, calcium is almost completely utilized as a pharmaceutical treatment to treat deficiency. Calcium shortage in the blood is so important to a wide range of biological processes that our internal biochemistry will not tolerate even a short-term shortfall.

Because man cannot manufacture vitamin C, it is an essential component of the diet. It's an extremely effective lowering agent. Vitamin C plays a vital role in the body's stress response. It's crucial in the fight against infection.

Dosage & Administration

Adults and children above 7 years: 1 effervescent tablet daily

Children 3 to 7 years: ½ effervescent tablet daily

Infants: As prescribed by the physician

Dissolve one tablet in half glass (100 ml) of water.

Interaction

Calcium gluconate: The combination of high-dose calcium and thiazide diuretics can produce milk-alkali syndrome and hypercalcemia. May enhance the toxicity of digoxin. Reduce the effect of calcium channel blockers. The absorption of calcitriol (a metabolite of vitamin D) is increased.

calcium carbonate: combined with thiazide diuretics or vitamin D can cause milk-alkali syndrome and hypercalcemia. The absorption of corticosteroids is reduced. Reduce the absorption of tetracycline, atenolol, iron, quinolones, alendronate, sodium fluoride, zinc fluoride and calcium channel blockers. It will increase the heart effect of digitalis glycosides and can promote digitalis poisoning.

Vitamin C: Deferoxamine, hormonal contraceptives, fluphenazine, warfarin, elemental iron, salicylate, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.

Contraindications

Hypercalcemia; severe hypercalciuria; severe renal failure (e.g., hyperparathyroidism, vitamin-D overdosage, decalcifying tumors such as plasmocytoma, bone metastases).

Hippoxaluria, glucose-6-phosphate dehydrogenase deficiency, and iron excess patients. Larger dosages can cause gastric distress.

Side Effects

Mild gastrointestinal problems (bloating, diarrhoea) might occur in rare situations. Long-term high-dose therapy in predisposed people may increase the development of calculi in the urinary system.

Pregnancy & Lactation

Oral calcium supplementation or antacid treatment with calcium-containing medications has been widely utilized in pregnancy. In lactating mothers, calcium carbonate can be used safely. Vitamin C can be consumed without risk during pregnancy and breastfeeding.

Precautions & Warnings

For patients with mild hypercalciuria (greater than 300mg=7.5mmol/24 hours), mild or moderate renal function impairment, or a history of urinary stones, it is necessary to monitor the excretion of calcium in the urine. If necessary, the dose should be reduced or treatment should be stopped. Unless otherwise specified, high doses of vitamin D and derivatives should be avoided during treatment with this preparation.

As citrate is reported to increase the absorption of aluminum, patients with severe renal insufficiency, especially those receiving aluminum-containing preparations, should use the drug with caution. Diabetes patients should pay attention to the sugar content.

Therapeutic Class

Specific mineral & vitamin combined preparations

Storage Conditions

Store in a cool, dry location away from light and moisture.

Pharmaceutical Name

Incepta Pharmaceuticals Ltd

Generic

Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C

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