Famotack Tablet 40 mg (10 Pcs)

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Indications

Famotidine is indicated for-

Short term treatment of active duodenal ulcer and benign gastric ulcer

Maintenance therapy for prevention of relapses of duodenal ulceration

Gastro-oesophageal reflux disease

Zollinger Ellison Syndrome

Therapeutic Class

H2 receptor antagonist

Pharmacology

Famotidine is a histamine H2-receptor antagonist. Famotidine completely inhibits the action of histamine on H2-receptors of parietal cell. It inhibits basal, overnight and pentagastrin stimulated gastric acid secretion. The H2-receptor antagonist activity of Famotidine is slowly reversible, since the drug dissociates slowly from H2-receptor.

Dosage & Administration

Duodenal ulcer: 40 mg at night for 4 to 8 weeks

Benign gastric ulcer: 40 mg at night for 4 to 8 weeks; Maintenance therapy: 20 mg at night for preventing the recurrences of duodenal ulceration

Gastro-oesophageal reflux disease: 20 mg twice daily for 6 to 12 weeks

Zollinger Ellison syndrome: The recommended starting dose is 20 mg every six hours. Dosage should then be adjusted to individual response. Doses up to 160 mg every six hours have been administered to some patients without the development of significant adverse effects

Dosage can be administered irrespective of meals. Antacids may be given concomitantly if needed.

Interaction

Famotidine does not interact with the cytochrome P450 linked drug metabolising enzyme system. So, no interactions have been found in man with Warfarin, Theophylline, Phenytoin, Diazepam, Propranolol, Aminopyrine or antipyrine.

Contraindications

There are no known contraindication to Famotidine. If any evidence of hypersensitivity appear, the therapy should be discontinued and consultation with physician is required.

Side Effects

Famotidine is generally well tolerated and side effects are uncommon. Dizziness, headache, constipation and diarrhoea have been reported rarely. Other side effects reported less frequently include dry mouth, nausea and/or vomiting, rash, abdominal discomfort, anorexia and fatigue.

Pregnancy & Lactation

Pregnancy: There are no adequate, well controlled studies on Famotidine in pregnancy, but it is known to cross the placenta and should be prescribed only if clearly needed.

Lactation: It is not known whether Famotidine is secreted into human milk, nursing mothers should either stop nursing or stop taking the drug.

Precautions & Warnings

Dosage reduction should be considered or interval between doses should be prolonged if creatinine clearance falls to or below 30 ml/min.

Storage Conditions

Tablet: Store between 15-30° C. Concentrate for injection: Store between 2-8° C.

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