Indications

As dietary supplement:

Vitamin E deficiency resulting from impaired absorption

Increased requirements due to diet rich in polyunsaturated fats

For healthy hair & skin

As an antioxidant

Hemolytic anemia due to Vitamin E deficiency

Therapeutic use:

Cardiovascular disease

Heavy metal poisoning

Hepatotoxin poisoning

Hemolytic anemia

Oxygen therapy

In nutritional deficiency states.

Therapeutic Class

Vitamin-E Preparations

Pharmacology

Vitamin E acts as an antioxidant in the body. Vitamin E protects polyunsaturated fatty acids (which are components of cellular membrane) and other oxygen-sensitive substances such as vitamin A & vitamin C from oxidation. In premature neonates irritability, edema, thrombosis and hemolytic anemia may be caused due to vitamin E deficiency. Creatinuria, ceroid deposition, muscle weakness, decreased erythrocyte survival or increased in vitro hemolysis by oxidizing agents have been identified in adults and children with low serum tocopherol concentrations.

Dosage & Administration

Betterment of cardiovascular health: 400 IU-800 IU per day

Deficiency syndrome in adults: 200 IU-400 IU per day

Deficiency syndrome in children: 200 IU per day

Thalassemia: 800 IU per day

Sickle-cell anemia: 400 IU per day

Betterment of skin & hair: 200 IU-400 IU per day (Topical use is also established for beautification)

Chronic cold in adults: 200 IU per day

Interaction

Vitamin E may impair the absorption of Vitamin A & function of Vitamin K and potentiates the effect of Warfarin.

Contraindications

No known contraindications found.

Side Effects

Overdosage (>1 gm) have been associated with minor side effects, including hypertension, fatigue, diarrhea and myopathy.

Pregnancy & Lactation

Vitamin E is safe in pregnancy and lactation, when used as recommended doses. Higher doses are not established.

Precautions & Warnings

It may increase the risk of thrombosis in some patients, such as those taking estrogens.

Use in Special Populations

Vitamin E is safe for children.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.