Indications of Atasin 20
When diet and other non-pharmacological approaches fail to lower increased total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglyceride levels in the following conditions, atorvastatin is prescribed as an adjuvant to diet.
- To lower total cholesterol and LDL cholesterol in patients with familial hypercholesterolemia, both heterozygous and homozygous.
- To treat patients with combined dyslipidemia who have high cholesterol and triglycerides (Fredrickson Type Ia and Ib).
- For the treatment of hypertriglyceridemia patients with increased blood triglyceride levels (Fredrickson Type IV).
- For the treatment of dysbetalipoproteinemia patients (Fredrickson Type III).
- Reduce myocardial ischemic episodes in people with asymptomatic or mild to moderate symptomatic coronary artery disease and high LDL cholesterol.
- Patients with hypercholesterolemia linked with or aggravated by diabetes mellitus or renal transplantation should have their total and LDL cholesterol levels reduced.
Pharmacology of Atasin 20
HMG-CoA reductase inhibitor atorvastatin is a selective inhibitor. The rate-limiting enzyme in the conversion of HMG-CoA to mevalonate, a precursor of sterols including cholesterol, is this enzyme. Atorvastatin reduces plasma cholesterol and lipoprotein levels via blocking HMG-CoA reductase and cholesterol synthesis in the liver, as well as increasing the number of hepatic LDL receptors on the cell surface, resulting in improved LDL uptake and catabolism.
Dosage & Administration
Primary hypercholesterolemia and combined hyperlipidemia-
- Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to the max. 80 mg once daily.
- Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 20 mg once daily.
Familial hypercholesterolemia-
- Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolemia).
- Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 80 mg once daily.
Prevention of cardiovascular events-
- Adults: Initially 10 mg once daily adjusted according to the response.
Interaction of Atasin 20
Concurrent use of cyclosporin, fibric acid derivatives, erythromycin, azole antifungals, and niacin increases the risk of myopathy while taking Atorvastatin. When Atorvastatin was used with antihypertensives or hypoglycemic medications, no clinically meaningful interactions were seen. If Atorvastatin is used with digoxin, erythromycin, oral contraceptives, colestipol, antacid, or warfarin, patients should be continuously watched.
Contraindications
Patients who are hypersensitive to any component of Atasin 20 should avoid taking it. Active liver disease or unexplained chronic transaminase increases are contraindicated with atorvastatin. It's also not recommended for patients who have had a significant reaction to HMG-CoA reductase inhibitors in the past.
Side Effects of Atasin 20
Atasin 20 is well tolerated by most people. Constipation, flatulence, dyspepsia, and abdominal pain are the most common Atorvastatin side effects. Infection, headache, back pain, rash, asthenia, arthralgia, and myalgia are some of the other side effects.
Pregnancy & Lactation
Atasin 20 is not recommended for use during pregnancy. There is no evidence of safety in pregnant women. There have been no controlled clinical trials with atorvastatin in pregnant women. There have been a few cases of congenital abnormalities following intrauterine exposure to HMG-CoA reductase inhibitors. Reproduction toxicity has been demonstrated in animal studies. The use of atorvastatin by the mother may lower the amount of mevalonate in the fetus, which is a precursor to cholesterol manufacturing. Women who are pregnant, trying to conceive, or fear they are pregnant should avoid using Atasin 20. Treatment with Atasin 20 should be stopped for the duration of the pregnancy or until the lady is no longer pregnant.
It is unknown whether Atasin 20 or its metabolites are excreted in human milk during lactation. The amounts of atorvastatin and its active metabolites in rats' plasma are similar to those found in milk. Breastfeeding is not recommended for women taking atorvastatin because of the risk of major side effects. Taking Atasin 20 while nursing is not recommended.
Precautions & Warnings
Effects on the liver: Liver function tests should be done before starting treatment and then on a regular basis after that. In patients who drink a lot of alcohol or have a history of liver illness, atorvastatin should be administered with caution. If severely raised CPK levels or myopathy is diagnosed or suspected, Atasin 20 medication should be stopped.
Therapeutic Class
Other Anti-anginal & Anti-ischaemic drugs, Statins
Storage Conditions
Keep away from light and heat in a dry location. Keep out of children's reach.
Pharmaceutical Name of Atasin 20
ACI Limited
Generic of Atasin 20
Atorvastatin Calcium
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